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5. Hacker, H. & Karin, M. Sci. STKE 2006, re13 (2006). 6. Baud, V. & Karin, M. Nature Rev. Drug Discov. 8, 33–40 (2009). 7. Mayo, M. W. et al. Science 278, 1812–1815 (1997). 8. Chien, Y. et al. Cell 127, 157–170 (2006). 9. Engelman, J. A. et al. Nature Med. 14, 1351–1356 (2008). 10. Dajee, M. et al. Nature 421, 639–643 (2003). Julian Downward is at Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK. e-mail: [email protected]